My research is on genetics, evolutionary biology and aquaculture of molluscs. I am interested in genetic mechanisms of molluscan development and adaption, and their applications in the improvement of cultured molluscs. Research in my lab may include basic studies towards a better understanding of molluscan biology and evolution, including studies on how genomic changes, meiosis and sex affect fitness and environmental adaptation. I also conduct applied research on genetic improvement of cultured molluscs as molluscan aquaculture plays an important role in sustainable seafood production. Applied research may include genetic analyses of economically important traits such as growth and disease resistance, and the development of new technologies for improving cultured molluscs through polyploidization and genomic selection.
Ximing Guo received his Ph.D. from University of Washington (Seattle). He joined the Haskin Shellfish Research Laboratory as a Postdoctoral Research Associate in 1992 and became a Research Assistant Professor in 1995. He was promoted to Associate Professor in 2001, Full Professor in 2007 and Distinguished Professor in 2019. Ximing is an Honored Life Member of the National Shellfisheries Association (USA). He has been directing the Shellfish Genetics and Breeding Program at Rutgers since 1998.
Guo, X., J.B. Puritz, Z. Wang, D. Proestou, S. Allen Jr., J. Small, K. Verbyla, H. Zhao, J. Haggard, N. Chriss, D. Zeng, K. Lundgren, B. Allam, D. Bushek, M. Gomez-Chiarri, M. Hare, C. Hollenbeck, J. La Peyre, M. Liu, K. E. Lotterhos, L. Plough, P. Rawson, S. Rikard, E. Saillant, R. Varney, G. Wikfors, and A. Wilbur. 2023. Development and evaluation of high-density SNP arrays for the eastern oyster Crassostrea virginica. Marine Biotechnology, 25:174-191. https://doi.org/10.1007/s10126-022-10191-3
Li, Y., K. M. Slavik, H. C. Toyoda, B. R. Morehouse, C. C. de Oliveira Mann, A. Elek, S. Levy, Z. Wang, K. S. Mears, J. Liu, D. Kashin, X. Guo, T. Mass, A. Sebé-Pedrós, F. Schwede & P. J. Kranzusch. 2023. cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell 186:3261-3276.e3220. https://doi.org/10.1016/j.cell.2023.05.038
Zeng, D., Guo, X. 2022. Mantle transcriptome provides insights into biomineralization and growth regulation in the eastern oyster (Crassostrea virginica). Marine Biotechnology, 24:82-96. https://doi.org/10.1007/s10126-021-10088-7
Guo, X., C. Li and H. Wang. 2018. Diversity and evolution of living oysters. J. Shellfish Res., 37(4):755-771. https://doi.org/10.2983/035.037.0407
Guo, X., and S.E. Ford. 2016. Infectious diseases of marine molluscs and host responses as revealed by genomic tools. Phil. Trans. R. Soc. Lond. B, 371: 20150206. http://dx.doi.org/10.1098/rstb.2015.0206
Guo, X., Y. He, L. Zhang, C. Lelong and A. Jouaux. 2015. Immune and stress responses in oysters with insights on adaptation. Fish & Shellfish Immunology, 46:107-119. http://dx.doi.org/10.1016/j.fsi.2015.05.018
Zhang, N., F. Xu & X. Guo. 2014. Genomic analysis of the Pacific oyster (Crassostrea gigas) reveals possible conservation of vertebrate sex determination in a Mollusc. G3: Genes| Genomes| Genetics, 4:2207-2217. https://doi.org/10.1534/g3.114.013904
Zhang, G., X. Fang, X. Guo, L. Li, R. Luo, F. Xu, et al (80). 2012. The oyster genome reveals stress adaptation and complexity of shell formation. Nature, 490:49-54. (http://dx.doi.org/10.1038/nature11413)
He, Y., H. Yu, Z. Bao, Q. Zhang and X. Guo. 2012. Mutation in promoter region of a serine protease inhibitor confers Perkinsus marinus resistance in the eastern oyster (Crassostrea virginica). Fish & Shellfish Immunology 33: 411-417.
Guo, X., Y. Wang, Z. Xu and H. Yang. 2009. Chromosome set manipulation in shellfish. Pp 165 – 195 in: New Technologies in Aquaculture: Improving Production Efficiency, Quality and Environmental management, G. Burnell and G. Allan (eds). Woodhead Publishing.
Tanguy, A., X. Guo and S.E. Ford. 2004. Discovery of genes expressed in response to Perkinsus marinus challenge in eastern (Crassostrea virginica) and Pacific (C. gigas) oysters. Gene, 338:121-131.
Guo, X., D. Hedgecock, W.K. Hershberger, K. Cooper and S.K. Allen, Jr. 1998. Genetic determinants of protandric sex in Crassostrea oyster. Evolution, 52(2):394-402.
Guo, X., G. DeBrosse and S.K. Allen, Jr. 1996. All-triploid Pacific oysters (Crassostrea gigas Thunberg) produced by mating tetraploids and diploids. Aquaculture, 142:149-161.