Mismatch between netcdf clients and hdf datasets, uint8 vs int8, uint16 vs int16, uint32 vs int32. Best way to resolve this is to use pure matlab client with these hdf datatypes, i.e. loaddap. Requires one to be familiar with the native data format and the data model of the client.

Matlab client has nasty habit of permuting dimensions.

NCO clients cannot currently write to a local file larger than 2GB.

OPeNDAP urls are ridiculously long.

Clients can be very difficult to compile, especially on solaris.